Elisabeth Sparkle, a fallen Hollywood idol pushing 50, sees her glittering world unravel after an agonising meeting with her TV producer. And just like that, years of contribution to the cut-throat entertainment industry went down the drain. Now, Elisabeth would do anything for another shot. Fortunately, she won't have to sell her soul to stay in the game; Elisabeth only needs to try The Substance. After all, she has nothing to lose--if Elisabeth plays her cards right, the miraculous solution will deliver on its wild promise. However, with so much at stake, there is always a temptation to cut corners when time is short. As an empowered new version of the once-beloved star emerges, so does a haunting question: How long can a beautiful lie deceive the world?