In a post-apocalyptic wasteland, a woman rebels against a tyrannical ruler in search for her homeland with the aid of a group of female prisoners, a psychotic worshiper, and a drifter named Max.

The former policeman Max is captured by the War Boys tribe, commanded by the Immortal Joe and assigned to be blood donor for the Wat Boy Nux who is sick. Meanwhile Imperator Furiosa drives a tank truck to collect gasoline for Joe. However her true intention is to flee from the tyrannical Joe with his five women selected to breed hidden in the truck to her homeland. Immortal Joe commands a party to hunt down Furiosa and Max is chained to Nux's car. Furiosa heads the truck into a sand storm but Nux continues to pursue her. After the storm, Max succeeds to escape from the car and brings Nux chained with him. He sees Furiosa and the five wives and decides to flee in their truck; but there is a secret to operate the truck and he teams up with Furiosa, leaving Nux in the desert. When Joe's gang arrives, they retrieve Nux and follow Furiosa. Will Max and the women succeed in escaping from Joe's gang?

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